The Non-Quality Controlled Lightning Imaging Sensor (LIS) on International Space Station (ISS) Science Data were collected by the LIS instrument on the ISS used to detect the distribution and variability of total lightning occurring in the Earth’s tropical and subtropical regions. This dataset consists of science data. These data can be used for severe storm detection and analysis, as well as for lightning-atmosphere interaction studies. The LIS instrument makes measurements during both day and night with high detection efficiency. The data are available in both HDF-4 and netCDF-4 formats.