This dataset includes field data, analysis code, and corresponding airborne imagery collected and generated during the 2022 NASA Surface Biology Geology (SBG) High Frequency Time series (SHIFT) campaign within Devereux Slough estuary in Santa Barbara County, California, USA. This campaign collected field data contemporaneously with weekly flights of the NASA's Airborne Visible-Infrared Imaging Spectrometer-Next Generation (AVIRIS-NG) facility instrument over the study areas. Soil samples were collected in North Campus Open Space and Coal Oil Point Reserve between 2022-02-24 to 2022-09-16 and analyzed for salinity (electric conductivity). Soil samples were paired with corresponding AVIRIS-NG flights, and AVIRIS-NG Level 2A Unrectified Reflectance data were used to derive fractional cover and vegetation and soil indices across the study area. Multiple endmember spectral mixture analysis (MESMA) was used to estimate fractional cover for four cover classes. Additionally, canopy response stress index, modified anthocyanin reflectance index, normalized difference vegetation index, and vegetation soil salinity index were derived. The data are provided in cloud-optimized GeoTIFF, ENVI, comma separated values (CSV) , and shapefile formats.