This data set provides total vertical column O2, CO2, CH4, CO, and H2O, as well as dry-air columns of CO2, CH4, CO, and H2O from airborne campaigns over the Alaskan and Canadian Arctic for the Carbon in Arctic Reservoirs Vulnerability Experiment (CARVE). The data represent the Level 2 Quick Retrieval (L2QR) data product collected using the CARVE Fourier Transform Spectrometer (FTS). Flight campaigns took place from 2012 to 2015 between the months of March and November to enable investigation of both seasonal and inter-annual variability in atmospheric gas content. The measurements included in this data set are crucial for understanding changes in Arctic carbon cycling and the potential threats posed by thawing of Arctic permafrost.