This dataset contains the Delft3D model of the Atchafalaya Basin along the Mississippi River Delta (MRD) in coastal Louisiana. Simulations cover the Delta-X Spring and Fall campaigns in 2021 and include hydrodynamics, waves, and sediment transport. Bottom friction was calibrated using AirSWOT water elevation data, while sediment parameters were calibrated using AVIRIS-NG Total Suspended Solids (TSS) data. All files required to run the simulations are included. Model output of water levels, velocity, and depth-averaged sediment concentration are provided for both campaigns as netCDF files. The dataset includes a netCDF file containing the annual inorganic mass accumulation rates derived from simulations.